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First in class neuroprotective small molecule for ischemic stroke
Patent number:
EP21382409
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Small molecule that stabilizes the retromer complex, showing strong neuroprotective effects in highly excitotoxic conditions and maintaining key neuronal survival proteins like KIDINS220 in validated in‑vitro models.
Countries:
Spain
Regions:
Community of Madrid
Centers:
CSIC
Other entities:
Sectors:
Health
Subsectors:
TRL Level:
TRL 3 – experimental proof of concept
BRL Level:
PDF Link:
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R55‑treated mice remained on the beam for a longer time during the walking test, exhibiting fewer falls and slips compared to vehicle‑treated animals. T2‑weighted MRI analysis further showed that R55 treatment significantly reduced infarct volume. Together, these results demonstrate the strong neuroprotective effect of R55 and support its clinical potential — along with related compounds — to prevent excitotoxic neuronal death and brain damage caused by ischemic stroke.
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