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SUPER-RESOLUTION 3D OPTICAL MICROSCOPE BY SCANNED STRUCTURED ILLUMINATION
WO20128130
It is a a new technology that is based on a hybrid combination of the above concepts. To be more specific, the invention is based on a smart combination of structured light with a scanned, pinholed, detection. This permits to obtain optical sectioning while doubling the lateral resolution without applying any post-processing operation or rotating the illumination pattern. In summary, the new invention reduces the computing time, avoids the formation of artefacts and provides 3D superresolution.
Applications: The invention could be applicable in any sector that requires the study of biological samples. Advantages: The system has significant advantages over existing ones: - It represents an advance with respect to systems that can offer similar benefits given its simplicity of both manufacture and use. - Increased resolution. - It does not require post-processing. - More economical than other systems on the market with similar features. - Easy implementation. - Reduction of fluorescent photobleaching and phototoxixity.