Aldoximes as NO donors, and their uses as plant architecture modifiers and in therapy
PCT/EP2023/071478
It relates to aldoximes or pharmaceutically acceptable salts thereof or isomers thereofable of releasing nitric oxide (NO) for use in the treatment of a condition or a diseasewhich is sensible to the action of the NO, wherein the treatment comprises administering10 the aldoxime to a subject and releasing NO from the aldoxime through an in vivoenzymatically catalyzed redox reaction at physiological pH, as well as to the in vivo use ofsuch aldoximes or acceptable salts for plants thereof or isomers thereof for biologicalapplications which are sensible to the action of the NO in plants, wherein the biological application is selected from the group consisting of plant rooting agent, plant structure 15 modifier, stimulators of the tolerance to abiotic or biotic stress, plant protector from stress induced by ammonium nutrition as an exclusive source of nitrogen, plants protector from hydric stress, and as germination inducer. It also relates to compositions comprising them.
Por un lado, las aldoximas descritas son aplicables en el ámbito de la salud humana y veterinaria, en la mejora de tratamientos de patologías relacionadas con la inflamación, como enfermedades vasculares, inflamatorias, tumorales o infecciosas. Por otro, son útiles en el ámbito de la agronomía y agricultura, como potenciadores de los sistemas radiculares en plantas, modificadores de la estructura de plantas, estimuladores de la tolerancia a distintos tipos de estrés o inductores de la germinación.



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