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IMMUNOGENIC COMPOSITION FOR THE PREVENTION OF MARINE TENACIBACULOSIS CAUSED BY TENACIBACULUM MARITIMUM AND TENACIBACULUM SOLEAE IN FISH, PRODUCTION METHOD AND USE
ES2939719
The invention discloses an immunogenic composition for the prevention of marine tenacibaculosis, a disease that affects marine and anadromous fish with great commercial value, comprising the strains Tenacibaculum maritimum CECT 30394 and Tenacibaculum soleae CECT 30393. The invention further includes its production method and the use thereof against said disease.
Administration by immersion of the fish in the composition diluted 1:1000 in seawater (2 baths of 2 minutes, separated by an interval of four weeks) or by injection (dose of 0.1 mL/fish) confers to the fish high levels of protection (RPS=70-100%) against marine tenacibaculosis caused by both pathogenic species This developed immunogenic composition is an advantage over the described experimental monovalent vaccines or the commercial ICTHIOVAC-TM vaccine, since it allows: 1) Improve antigenic coverage by including strains of the species T. marítimum and T. soleae, the main causes of tenacibaculosis worldwide. 2) Protect against tenacibaculosis caused by T. maritimumyT. soleaea fish species of great commercial interest.