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Advanced Bioreactor Chamber for Controlled Tissue Growth and Functional Maturation
EP4644528A1
This technology relates to an advanced bioreactor chamber for growing and maturing engineered tissues under controlled and physiologically relevant conditions. The system combines a flexible, permeable support for cell growth with precisely controlled mechanical stimulation, generated by the intermittent contact of a pressure surface, enabling cyclic deformation of the developing tissue. The bioreactor allows cells to better mimic in vivo mechanical environments, promoting tissue maturation, functionality and structural integrity. Its design supports long‑term culture with controlled nutrient, gas and stimulation conditions and can integrate mechanical, electrical and environmental stimulation within a single chamber. The technology is suitable for applications in cardiac, muscular and other regenerative tissues, offering a scalable and robust platform for tissue engineering, regenerative medicine and advanced therapy development.
Direct, physiologically relevant stimulation Applies controlled, intermittent mechanical deformation that closely mimics in‑vivo tissue dynamics, improving tissue functionality versus fluid‑driven or static systems. Closed, single‑chamber design Integrates culture and stimulation in one sterile system, minimizing contamination risks and handling complexity. Uniform and reproducible tissue maturation Perimetral fixation of a flexible support enables homogeneous deformation across the tissue, enhancing consistency and quality. Scalable and versatile platform Compatible with multiple tissue types and biomaterials, supporting broad application in regenerative medicine and ATMP development. Translational and clinical‑ready Removable supports facilitate analysis, transfer, and downstream clinical use, accelerating preclinical‑to‑clinical translation.