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New peptides to treat cognitive impairment of age-related diseases
Patent number:
EP25382703
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Novel Folate Receptor alpha (FRα) binding peptides induce brain cell reprograming and rejuvenation, enhancing cognitive function in aged mice. These unique peptides are able to cross the blood-brain barrier and specifically bind to FRα in brain cells.
Countries:
Spain
Regions:
Community of Madrid
Centers:
CSIC, UNIVERSIDAD AUTONOMA DE MADRID
Other entities:
Sectors:
Health
Subsectors:
TRL Level:
TRL 4 – technology validated in lab
BRL Level:
PDF Link:
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Applications
• Cognitive improvement of recognition and spatial memory. • Specific binding to neuroepithelial FRα, preventing from systemic toxic effect associated to high-doses of folate administration. • Blood-brain barrier permeability, enabling versatile administration routes, including intracranial, peritoneal and intragastric. • Safety and efficacy proven in pre-clinical mouse models.
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