COMBINATIONS WITH THIAZOLIDINEDIONES FOR USE IN THE PREVENTION OR TREATMENT OF ABNORMAL BONE GROWTH

This new technology offers a disruptive approach to the blockade of the abonormal bone growth, through the inhibition of osteoblast differentiation and the promotion of the adipogenic one, which are opposing mechanisms. This can be implemented in clinical practice individually or in combination with present therapies. Currently there is no effective and non-aggressive treatments for these diseases. The use of bisphosphonates as prophylactics lacks evidence, surgical removal depends on certain factors, and radiotherapy is considered an aggressive and non-specific treatment. Certain antiinflammatory drugs have shown some effect in preventing HO. Nevertheless, these last medications to prevent HO only show partial results. Therefore, finding an effective and non-aggressive treatment to prevent the formation of heterotopic bone is a medical need, and our therapy accomplish these requisites.