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FUNCTIONALIZED PARTICLES PROTEIN LIGANTS, METHOD OF OBTAINING AND CARTRIDGES OF DIALYSIS CONTAINING SUCH PARTICLES (MACHINE-TRANSLATION BY GOOGLE TRANSLATE, NOT LEGALLY BINDING)
ES2691146
The present invention describes copolymer particles of styrene and methyl methacrylate functionalized on its surface with polyethylene glycol methacrylate. This material allows the immobilization on its surface of proteins through covalent binding. The invention describes the process for obtaining the particles and their use in the elimination of toxic compounds present in the blood refractory to dialysis treatments, such as excess bilirubin. The invention also writes dialysis cartridges containing the functionalized particles bound to proteins such as albumin, compatible with the current dialysis systems. (Machine-translation by Google Translate, not legally binding)
The present invention describes copolymer particles of styrene and methyl methacrylate functionalized on its surface with polyethylene glycol methacrylate. This material allows the immobilization on its surface of BSA through covalent binding. The main advantages are: - Higher specific Surface for bilirubin adsorption - Low blood pressure droop in the dialysis systems - The attachment of albumin to the particles played a key role to selectively reduce the bilirubin levels in blood