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COMPOUNDS AND METHODS FOR TREATING CANCER
The invention relates to compounds and compositions capable of silencing, in a specific manner, the mRNA of isoform beta of the PIAS2 protein, as well as to the use thereof for the treatment of cancer, and particularly anaplastic carcinoma of the thyroid.
Treatment with a molecule complementary to a target region of the PIAS2β mRNA that together with its target sequence produces the inhibition of the expression of PIAS2β mRNA. Our studies suggest that this could be an alternative for the treatment of PDTC and ATC thyroid cancers. Besides, this therapy would have lower side effects, as normal cells have not been affected in the assays performed. There could be a potential application of this treatment for other anaplastic or undifferentiated types of cancer (undifferentiated pancreatic, lung and gastric carcinomas).