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RECOMBINANT NANNOCHLOROPSIS GADITANA PROTEIN
WO21044073
The present invention relates to the use of a recombinant protein as a cancer growth inhibitor, specifically to the use of the recombinant prohibitin UCA01, which is a protein that immerses the cell in a period of miotic inactivity in the case of cancer cells. In this way, the protein prevents cancer growth and the onset of same. UCA01 prevents the onset of cancer, owing to three factors: its antioxidant capacity; increased p53 protein activity; and protection of the mitochondria against degradation. Specifically, the invention shows, for the first time, the biological activity of the recombinant protein UCA01, extracted from microalgae (Nannochloropsis gaditana). Before this invention, wild UCA01 protein was initially classified as a hypothetical protein in the National Center for Biotechnology Information (NCBI) (accession: XM_005854224.1).
The activity of the recombinant protein of the invention (UCA01) as an antitumor provides a tool to fight cancer, based on a protein from a microalgae. Inhibition occurs at low concentrations compared to other biological activity assays on other proteins, indicating a new method and a new source for obtaining UCA01. source of obtaining UCA01, efficient, since the quantities required to carry out its antitumor activity have been minimal.
P201930775