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MEDICAL USES OF APOLIPOPROTEIN A AND ACTIVATORS THEREOF
US2020378993
The present invention relates to the use of apolipoprotein A, a mimetic peptide thereof, or an activator thereof for the preparation of a medicinal product for the treatment or prevention of cancer. The invention also relates to a method for determining the stage of a colorectal tumor in a patient, where the method comprises determining ApoA1 levels in a biofluid from said patient, wherein decreased ApoA1 levels with respect to a reference value indicate a more advanced stage of the tumor, as well as a method for selecting treatment for a cancer patient, where the method comprises determining ApoA1 levels in a biofluid from said patients, wherein decreased ApoA1 levels with respect to a reference value indicate that the therapy of choice is a therapy based on apolipoprotein A, a mimetic peptide thereof, or an activator thereof.
Apolipoprotein A, a mimetic peptide thereof, or an activator thereof are capable of inhibiting the proliferation, migration, and invasion of cancer cells, particularly cancer cells having an overexpression of ABCA1. Patients diagnosed with tumors in advanced stages of the disease have decreased ApoA1 expression levels in a tumor sample with respect to patients diagnosed with tumors in earlier stages. Patients suffering from metastasis have decreased plasma ApoA1 levels with respect to patients diagnosed with a primary tumor.