ANDROGRAPHOLIDE DERIVATIVE FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES ASSOCIATED WITH A CYTOKINE STORM

Patent number:

WO22090605

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AG5 andrographolide derivative for use in the treatment of the inflammatory reaction caused by a cytokine storm, particularly produced by CoViD-19, bacteria with superantigens or by CAR-T, TIL or BiTE cell therapies.

Countries:

Spain

Regions:

Valencian Community

Navarre

Centers:

CSIC, UNIVERSITAT DE VALENCIA, UNIVERSIDAD PUBLICA DE NAVARRA, FUNDACION PARA LA INVESTIG MEDICA APLICADA, UNIVERSITAT POLITECNICA DE VALENCIA, UNIVERSIDAD DE NAVARRA, FUNDACION PARA LA INVESTIGACION MEDICA APLICADA

Other entities:

Sectors:

Health

Subsectors:

Pharmaceuticals

TRL Level:

TRL 4 – technology validated in lab

BRL Level:

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Video Link:

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Sustainable Development Goal:

Applications

- Compuestos semi-sintéticos de síntesis sencilla a partir de un compuesto natural (que se comercializa). - Presentan actividad antiinflamatoria e inmunomoduladora muy potente testada en células in vitro y en modelos in vivo de inflamación (pez cebra, ratón). - No son mutagénicos y no presentan toxicidad en organismos modelo. - Se pueden administrar por vía parenteral o por vía oral. - Se está completando el paquete de preclínica regulatoria y se está colaborando con empresas para su escalado industrial. - Se está planificando un ensayo clínico (fases I y II) en pacientes de COVID-19.

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