Peritoneal dialysis solutions containing a natural flavonoid as an osmotic agent

Advantages: -Greater safety compared to glucoseTroxerutin has lower cellular toxicity and causes less induction of EMT (epithelial-mesenchymal transition) in mesothelial cells.It reduces peritoneal membrane fibrosis and local inflammation in animal models. -High osmotic efficacyUltrafiltration capacity comparable to 4.25% glucose solutions, but using lower concentrations (1–3% w/v).Appropriate molecular weight ($743\text{ Da}$) allows for daily exchanges without the limitations of higher-weight agents (like icodextrin). -Beneficial pharmacological properties: Anti-inflammatory and antioxidant. May protect organs such as the heart from complications associated with traditional peritoneal dialysis. Applications: Chronic kidney disease treatment: Substitution of glucose in peritoneal dialysis for patients with renal failure.