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IN VITRO METHOD FOR PREDICTING AND/OR FORECASTING THE COMPATIBILITY OF BIOMATERIALS IN A PATIENT
WO18115553
The present invention relates to a set of markers, preferably proteins, all associated with the path of the system for activating the complement, which are particularly useful for predicting and/or forecasting the compatibility in vitro of a biomaterial, for example such as prosthetic joints, dental prostheses, valves, stents, etc. in the patient. In addition, the present invention comprises an in vitro method for predicting and/or forecasting the compatibility of said materials by determining the peptide profile described in the invention, as well as a kit and/or a device for carrying out said method.
Through this invention it is possible to identifiy “in vitro” a profile of markers, preferably protein markers, most of them related to the pathway of the complement activation system, where their determination and/or quantification is able to predict and/or prognosticate the biocompatibility of biomaterials, preferably implantable biomaterials, medical devices, or other type of prosthesis, such as stents, cannulae, pacemakers, dental implants. USE • Prediction of biocompatibility. • Prognosis of biocompatibility. ADVANTAGES • Currently, there is not known an accurate and simple method for the prognosis of biocompatibility. • Easy-to-use method.