CELL PENETRATING PEPTIDES

The present invention relates to a cell penetrating peptide with or without a ligand comprising a scaffold of at least two hydrophobic blocks and at least two cationic blocks, each cationic blocks alternating with one hydrophobic block; wherein the total number of amino acids is comprised between 5 and 40, and wherein each of said hydrophobic blocks individually considered consist of one or more hydrophobic amino acids, wherein at least one of said hydrophobic amino acids is selected from the group consisting of leucine, alanine and isoleucine; wherein said at least two hydrophobic blocks comprise at least a leucine amino acid; and each of said cationic blocks individually considered comprise at least one cationic amino acid having a side chain comprising a nitrogen atom, preferably one which is protonated under physiological conditions.