Topical formulations to restore physiological flow in Lipid-obstructed glands

• Problem: Obstruction of physiological ducts due to lipid accumulation is a common yet under-addressed problem affecting multiple glandular systems. These conditions share a common underlying mechanism: impaired ductal clearance and lipid buildup, highlighting the need for a unified, targeted solution to restore physiological flow and glandular function.  

• Context: In the Bartholin glands, duct blockage can result in painful cysts or abscess formation; within sebaceous glands, lipid retention contributes to acne and inflammation; sweat glands (eccrine and apocrine) may become obstructed, leading to conditions such as miliaria or hidradenitis suppurativa; mammary ducts can develop blockages associated with mastitis or ductal inflammation; meibomian gland dysfunction leads to tear film instability; and salivary glands may suffer from sialolithiasis, where lipid and mineral accumulation obstruct normal flow.  

• Type of solution searched for: The envisioned solution is a topical medical device designed to locally restore ductal patency by targeting lipid accumulation at the site of obstruction. A topical approach is preferred because it enables direct, localized action, minimizing systemic exposure and associated side eƯects while allowing for non-invasive, repeatable application across diƯerent gland types. This modality is particularly suitable for superficial or accessible glands. A mechanism of action based on the penetration of a lipid-solubilizing active compound can be also considered.

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