Startups Directory

Spin-off company from the Universidad Politécnica de Madrid developing thermal energy storage solutions for industrial decarbonization.

Industrial processes decarbonization

Reducing fossil fuel consumption and CO2 emissions. Generating direct and indirect specialized jobs

250 to 350k€

500k€

RoboKinetics aims to democratise advanced neurological rehabilitation through a patented robotic platform capable of optimising clinical resources and improving treatment efficiency. Our 6‑DOF isokinetic technology, unique in the market, transforms an elite, complex and costly therapy into an accessible, efficient and automated treatment, positioning us to lead a €1 billion robotic rehabilitation market.

Problem: STROKE (CVA) Isokinetic therapy is the gold standard for upper‑limb rehabilitation, but its high cost, complexity, and need for constant supervision limit it to single–degree‑of‑freedom machines used mainly with elite athletes. As a result, the vast market of neurological recovery (e.g., post‑stroke) remains underserved. Our Solution The core innovation lies in its ability to deliver full 6‑degree‑of‑freedom (6D) motion control (3D translation + 3D rotation), enabling natural, multi‑joint movements essential for neurological recovery. Unlike other systems, RoboKinetics adapts assistance or resistance in real time to the patient’s movement profile and physical condition. Its “programming by demonstration” interface drastically reduces setup time and empowers clinicians.

Our technology broadens access to high‑quality rehabilitation by delivering adaptive, 6‑degree‑of‑freedom therapy at a fraction of today’s cost and complexity. It accelerates recovery for stroke survivors, reduces pressure on healthcare systems, and supports clinicians with more efficient, data‑driven workflows. As the population ages and demand for rehabilitation grows, it offers a scalable solution that improves patient outcomes while strengthening the sustainability of care.

250K€

250K€-500K€

MG Biomed is a technology-driven company focused on preventing frailty and disability in older adults by combining IoT sensors, artificial intelligence, and personalized interventions. Its platform enables continuous, non-intrusive monitoring of functional status to support healthcare professionals, caregivers, and seniors in promoting active aging and improving quality of life. Originating from collaborative research with clinical and academic institutions, MG Biomed integrates data-driven insights into tailored solutions that enhance autonomy and well-being in the older population.

Ageing

Preventing functional decline, frailty and disability in the ageing population

500.000€

500.000€

At COLFEED4Print, we are dedicated to revolutionizing the printing industry through innovative solutions and sustainable practices. We are a company founded as a technological spin-off of the Colloidal Processing group of the Spanish National Research Council (CSIC) and our mission is to provide innovative products for additive manufacturing that focus on bone and tissue regeneration, energy and catalytic systems and high-resistance materials. We aim to meet the demand for advanced materials for new processing challenges, while promoting a circular economy, free of waste and environmentally neutral. We don’t just sell standard filaments; we manufacture multi-component filaments that enable researchers and companies working in manufacturing all over the world to meet the new industry 4.0 challenges. We are experts in adapting the product to each application in order to meet the expectations of our customers and achieve the best of results.

At COLFEED4Print, we develop innovative materials that enhance 3D printing capabilities and open new possibilities for industrial production and prototyping. Our scalable manufacturing process enables the fabrication of tailored materials with unlimited formulations, enhanced mechanical properties, printability, and biocompatibility, meeting specific industry needs.

By combining innovation, sustainability, and customization, COLFEED4Print is redefining next-generation additive manufacturing solutions.

500000 euros

0

Sanzar Group develops deep-tech across four lines: an ADCS/ACS system to improve satellite pointing and agility, the “Logistic Flying Car” project for door-to-door logistics, surgical robotics systems, and a SaaS mapping/analytics platform for precision agriculture powered by satellite imagery and AI.

Satellite Agility & Coverage Limitations: Traditional reaction wheel systems severely limit satellite reorientation speed and operational coverage. Our ADCS/ACS system solves this with ultra-high precision pointing and exceptional agility, enabling satellites to capture significantly more imagery and data per orbit.​Constellation Economics & Efficiency: In a real-world scenario covering Huvadhu Atoll (3,152 km²), our ADCS requires only 1 satellite versus 2 satellites with traditional reaction wheels, a 50% constellation reduction. This translates to lower CAPEX (fewer satellites to build and launch), reduced operational costs (maintenance, ground stations, operations), simplified mission design, and faster deployment to full operational capability.​Size & Mass Constraints: Our compact design (less than 1U) is smaller and lighter than conventional systems, making it ideal for small satellite platforms from 3U to 30U, maximizing payload capacity while maintaining superior performance. Mission ROI: By covering more area per pass with higher agility, operators achieve better performance at lower total mission cost, reducing infrastructure requirements, operational complexity, and time-to-market for constellation deployment.

Sanzar Group's ADCS technology will significantly impact society by making satellite-based Earth observation more accessible and affordable through superior efficiency, requiring 50% fewer satellites to achieve the same coverage compared to traditional systems. This increased efficiency enables more frequent and cost-effective monitoring of critical environmental changes, agricultural conditions, disaster response, and climate patterns, democratizing access to space-based data for governments, research institutions, and commercial operators worldwide. By reducing constellation costs and improving satellite agility, the technology accelerates deployment of services that address global challenges including food security, climate action, and sustainable resource management, ultimately making space technology a more practical tool for solving pressing societal problems.

500.000€

1M€

SIROCO is a project whose main objective is the development of a new concept of soft intelligent cervical orthoses with embedded sensors and actuators with the purpose of being used by users in order to 1) monitor their neck movements and 2) perform in two ways: a) passive mode, where the cervical orthosis simply sustains the neck but does not perform active movements on it, and b) active mode, where the cervical orthosis actuators perform movements on the neck in order to achieve specific head positions.

LightForge creates custom, ad-hoc light sources to perform several characterizations on different materials, according to the client's necessities.

Our main product gives the client a huge versatility to perform several material characterizations related to illumination, solving problems related with classic light sources.

Performing better characterizations means better quality on results, leading to higher quality material research.

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Hispansion is a Spanish deep-tech startup founded in 2024 and incubated at the ESA Business Incubation Centre (ESA-BIC). The company specializes in the development and production of high-fidelity lunar regolith simulants; materials engineered to replicate the chemical, mineralogical, and mechanical properties of the Moon’s surface. These simulants enable realistic testing of space technologies such as ISRU (In-Situ Resource Utilisation), lunar mobility systems, materials engineering, and infrastructure construction.

Hispansion solves the lack of high-fidelity, consistent, and safe lunar regolith simulants needed to test and validate lunar technologies on Earth, enabling reliable R&D and qualification for ISRU, mobility, excavation/handling, dust mitigation, construction, and sensor/instrument testing without relying on scarce, non-representative, or poorly characterized substitutes.

It accelerates safer and more cost-effective development of lunar missions and space technologies, reduces R&D waste by enabling reliable ground testing, and supports spin-offs in materials, robotics, and advanced manufacturing that can benefit industries on Earth.

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IA boutique for the renewable energy sector

Renewable energy forecasting, demand forecasting, BESS optimization, electricity go to market strategies

It helps renewable energy integration

1M euros

1M euros

Precision for Health is a company specialising in applied genetics to improve wellbeing and performance. They offer genetic tests that analyse how genetics influence ageing processes and metabolic health, providing personalised information for better care of the body and mind. Founded in 2018, the company has its origins in IMDEA Food, and focuses on improving athletic performance and wellbeing during ageing.

Understanding of the impact of nutrition on personalised health

Better genetic knowledge to apply precision nutrition

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Founded by researchers from IMDEA NUTRICIÓN, we perform microbiota analyses for diagnostic, scientific and clinical purposes at our laboratory in Madrid.

Microbiota and health The importance of microbiota for our health is widely accepted, and the consumption of food supplements containing prebiotics and probiotics has become extremely widespread. However, in order to contribute effectively to the restoration of this complex ecosystem, it is necessary to further the scientific study of the interrelationships between our organism and the microorganisms that coexist with us. Nevertheless, significant changes in our lifestyle, eating habits and, in particular, the widespread use of antibiotics have caused major imbalances in this ecosystem, imbalances that have been associated with numerous disorders.

Improves quality of life and eating habits

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60Nd is a deep-tech spin-off from Universidad Carlos III de Madrid (UC3M) that is redefining mechanobiology through its proprietary NeoMag® technology. We develop advanced instrumentation designed to study cellular responses to mechanical stimuli with unprecedented precision and throughput.

NeoMag® addresses the lack of physiological relevance in drug discovery and biomedical research, where current static models fail to replicate the mechanical forces of living tissues, significantly contributing to clinical trial failures.

60Nd’s technology will significantly impact society by accelerating the development of more effective therapies for critical conditions such as cancer, traumatic brain injury, and cardiovascular diseases. By integrating "mechanical reality" into drug discovery, our NeoMag® platform increases the predictive power of in vitro models, reducing the high failure rates of clinical trials and the associated multi-billion dollar costs. Furthermore, it promotes ethical scientific progress by providing a high-fidelity alternative that directly reduces reliance on animal testing, while strengthening European technological sovereignty in the high-growth biomedical instrumentation sector.

2.5M€

2.5M€

We build neurotechnology for mental health. A headset to use at home that identify, tracks and alleviates issues such as depression, anxiety and PTSD, integrating with psychotherapy to make the process more effective and efficient.

Mental health diagnosis, treatment and treatment adhesion.

Mental health impacts life in all aspects: from personal wellbeing to work productivity and even democratic and institutional health. In the worst case scenarios, it leads to suicide, the first cause of death among younger people. Mental health costs in the EU alone as much as the GDP of Sweden, making it 3 times more expensive than all cancers combined. Any technology that changes this trend is going to have a deep impact.

250.000€

250.000€

FoodSome Exosome Technologies S.L. is a knowledge-based spin-off specializing in exosome and extracellular vesicle (EV) technologies. We develop and protect proprietary, patented eco-friendly systems to isolate highly pure exosomes and EVs at large scale from food-grade sources, facilitating regulatory approval. Our customizable platforms enable the loading of active compounds for applications across the pharmaceutical, nutraceutical, and cosmetic industries. We provide project-driven solutions with EV purity levels tailored to the intended end use.

Our technology addresses the challenge of delivering biologically active compounds that are unstable, rapidly degraded, metabolized, or poorly absorbed. It enables targeted delivery of active molecules to specific tissues using a novel, natural nanotechnology based on exosomes and extracellular vesicles.

Our technology will positively impact society by enabling safer, more effective, and more sustainable delivery of bioactive compounds. By improving the stability, absorption, and targeting of active ingredients, it enhances the efficacy of pharmaceutical, nutraceutical, and cosmetic products, potentially reducing required dosages and side effects. The use of food-grade, natural nanocarriers and eco-friendly production processes supports regulatory compliance, consumer safety, and environmental sustainability, while accelerating innovation and access to next-generation therapies and wellness solutions.

500.000€

0

At CLAP we maximize virtual human embodiment. We focus on enabling realistic virtual interactions, bridging the gap between the real and digital worlds. Thanks to this vision, we are able to digitize a wide variety of processes, including the diagnosis and rehabilitation of mobility disorders such as those related to Parkinson's disease or multiple sclerosis.

The digital interaction is very poor. Options are limited to the use of controls or predefined hand gestures, which force a counterintuitive interaction and hinder learning, especially for novice users. Furthermore, the range of movement and interaction capabilities are extremely limited. In the field of physical therapy rehabilitation, diagnoses are slow, highly manual, and prone to error. Therapies are too general and do not take into account each patient's individual circumstances, leading to high dropout rates.

Improved mobility and autonomy for people with motor disorders, thanks to more effective and reliable diagnostic and rehabilitation processes.

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