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SELF-IMMOLATIVE MICELLE, METHODS AND USES THEREOF
EP25165757
The present disclosure relates to the fleld of pharmaceutical carriers, particularly a self-immolative micelle as a drug delivery system for the treatment of tumours, namely solid cancer, in particular in the treatment of pancreatic ductal adenocarcinoma (PDAC) and its metastases. The present disclosure also encompasses the production of the micelle and a pharmaceutical composition, namely hydrogel composition.
- Tumour-triggered drug release; - High local retention; - Enhanced efficacy with reduced toxicity; - Flexible modularity for other payloads; - Compatibility with accelerated regulatory paths. Primary: Platform for local chemotherapy delivery in solid tumours. Initial PoC: Pancreatic ductal adenocarcinoma (PDAC). Expandable to: Glioblastoma, peritoneal, head and neck, prostate, Lung Adenocarcinoma.