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METHOD FOR DETECTION OF AN ANALYTE
US2020284787
The present invention provides a method for in vitro detection and/or quantification of an analyte in aqueous or biological fluids based on monitoring the variation of the dynamical magnetisation signal of functionalized magnetic nanoparticles after their specific interaction with an analyte. The invention also provides a method for measuring the efficacy of a treatment of a disease in a subject, a method of diagnosis of a disease in a subject, as well as an apparatus for carrying out the three methods.
The device exhibits more than an order of magnitude than conventional devices. An example of available data is: The present application has been developed in a commercial device that works with magnetic nanoparticle concentrations of 1 mg/mL and preferential volumes around 50 microlitres, while frequency values between 5 kHz and 0.25 MHz such as 100 kHz, are typically used in the method of the present invention to detect different analyte contents down to 0.233µM.
Product already commercial, with ability to evolve to other use cases beyond research labs