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THERAPEUTIC TREATMENT AGAINST GLIOBLASTOMA CANCER
EP21383180.3
The perivascular cells that surround the small blood vessels of vascularized tissues, known as "pericytes", are useful for developing a cell therapy against glioblastoma cancer, if the activity related to a protein degradation mechanism by which glioblastoma is previously eliminated. parasitizes the pericyte, and is known as “chaperone-mediated autophagy”. The purpose of this patent is to protect the method of isolation and in vitro production of these cells, as well as their use as a pharmaceutical composition.
- Modified pericytes can act as a "drug cell" against brain tumors. - The modified pericytes are capable of promoting the activation of the endogenous pericytes of the host itself and of other cells of the immune system that allow the elimination of the tumor. - The proposed strategy could be applied to the treatment of other types of tumors. - Modified pericytes may act as secreting cells for potential glioblastoma prognostic markers.