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CARBOSILANE DENDRIMERS COMPRISING POLYPHENOL GROUPS, AND USES THEREOF
WO17220831
The invention relates to carbosilane dendrimers comprising polyphenol groups, and uses of same. The invention describes carbosilane dendrimers containing polyphenol groups within the structures thereof. In addition, the invention relates to a method for producing said carbosilane dendrimers comprising polyphenol groups and to the uses thereof as antioxidants (radical scavengers) and anti-tumour agents for use in the cosmetic and pharmaceutical industries.
The dendritic nature gives these derivatives a nanoscopic size and a multivalence (capacity to accommodate multiple groups on its surface) that can favor the properties of these compounds. The carbosilane nature of these derivatives gives them a hydrophobic character which can help them to interact with biological membranes, enhancing their activity. By having polyphenolic groups (GPF) in their structure, they are able to give characteristic properties to the dendritic molecule by functionalizing its surface, in such a way that they can act as powerful antioxidants and free radical scavengers. The compounds of the invention may be used alone or in combination with one or more compounds of the invention, or in combination with one or more different drugs (or any combination thereof). Greater stability against degradation and Ease of diffusion through biological barriers, and therefore access to target cells.