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METHOD FOR DIAGNOSING CANCERS IN ORAL AND PHARYNGEAL MUCOUS
WO15086867
The invention relates to a method for diagnosing cancers in the pharynx and oral cavity using Raman spectroscopy, which comprises the quantification of the intensities and areas of a diversity of the Stokes bands of the spectrum, and the definition and calculation of indices that result from dividing the areas of two different bands. The diagnosis is determined by the proximity of the values of said indices to the values previously obtained in normal cells and in cancerous cells.
It allows the analysis of both in vitro and ex vivo samples in the laboratory using conventional Raman equipment. <p> It is applicable to different types of cancer (neoplasms), including those of the upper aerodigestive tract, stomach, colon, bladder, breast, bone, lung, liver and prostate. <p> It is applicable to the diagnosis of neoplasms at different stages, such as oral leukoplakia, hyperplasia, mucosal dysplasia (mild to severe), which can be considered as pre-malignant or potentially malignant lesions, prior to the appearance of clinical and pathological manifestations, thus allowing the early diagnosis of oral cavity cancer. <p>