MAGNETIC NANOPARTICLES FOR USE IN THE TREATMENT OF TUMORS

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The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated; the invention also relates to the pharmaceutical compositions comprising such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

Countries:

Spain

Regions:

Galicia

Centers:

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Other entities:

Sectors:

Chemicals

Subsectors:

Biotechnology, Pharmaceuticals

TRL Level:

TRL 3 – experimental proof of concept

BRL Level:

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Sustainable Development Goal:

Applications

The present invention provides a novel cubic-shaped iron oxide-based magnetic nanoparticle functionalized with a platinum-based chemotherapeutic agent and a targeting agent comprising an antibody or a fragment thereof having a specificity against an overexpressed receptor in a given form of tumor; this nanoparticle is useful for carrying out a combined oncological therapy of hyperthermia and chemotherapy for that tumor form.

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