.jpg)
FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF
EP4178948A2
The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
The inventors have used new methods for the synthesis of functionalized isonitriles. The isonitriles of the invention are particularly useful for the study and manipulation of biological systems and further development of new functional materials.