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TREATMENT OF CANCER HARBORING MUTATIONS IN THE TP53 GENE AND/OR POST- TRANSLATIONAL MODIFICATIONS IN THE P53 PROTEIN WITH PARVOVIRUSES
EP19827705; CA3,124,187; US17/416,255; CH2019800927494
Treatment of cancer harboring mutations in the TP53 gene and/or post-translational modifications in the p53 protein. The present invention relates to the use of viruses belonging to the family Parvoviridae, genus Protoparvovirus, or combinations of such viruses with chemotherapy drugs, in the treatment of cancer. In particular the cancer is characterized by showing mutations in the TP53 gene and/or post-translational modifications in the p53 protein.
The invention demonstrates an effective treatment of various types of cancers characterized by presenting mutations in the TP53 gene and/or a post-translational modification in the p53 protein, when the parvoviruses of the invention are used, achieving a synergistic effect in combination with genotoxic chemotherapeutic agents.