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NANOSTRUCTURE LIPID SYSTEM
EP3820455A1
The present invention is related to systems of administration of enzymes or other proteins, preferably for use in enzyme replacement therapy (ERT), in particular for the treatment of Lysosomal diseases. In particular, the invention encompasses the preparation of a composition based on nanostructured lipid systems and its use in the manufacture of a therapeutic product.
The present invention provides a pharmaceutical nanostructured lipid system (hereafter referred to as: " nanostructured lipid system of invention " or "composition of the invention"), preferably for use in ERT, as a vehicle for transporting enzymes or other proteins, which allows improving distribution, stability and availability of the protein at the cellular level, allowing the protein release during longer periods of times and reaching important target tissues, such as brain tissue, skeletal muscle, bone and cartilage. In the concrete case of ERT, the composition of the invention increases the plasmatic enzyme stability promoting the intracellular internalization of the Lipid System Nanostructured carrier at the lysosomal levels where it progressively releases the enzyme.