New morin-derived compounds, procedure for obtaining them, and their uses

The present invention relates to the synthesis of new morin-derived compounds (specifically Schiff bases) designed as photoprotective agents to prevent skin damage caused by ultraviolet (UV) radiation, such as photoaging and skin cancer. Likewise, it seeks to optimize the chemical stability and absorption capacity of morin (a natural flavonoid) to make it more effective in pharmaceutical and cosmetic formulations. Furthermore, it proposes a simple synthetic route to reduce the environmental impact and the use of resources (such as water) associated with the traditional extraction of natural products. The invention utilizes the carbonyl group of morin to create Schiff bases through condensation reactions with nitrogenous reagents. The two main highlighted derivatives are: Morin oxime, obtained by reacting morin with hydroxylamine hydrochloride, and Morin semicarbazone, obtained through the reaction with semicarbazide hydrochloride. The results demonstrate that both derivatives possess a significantly higher UV-visible light absorption capacity than morin. In addition, these nitrogenous derivatives exhibit significant antioxidant and anti-inflammatory activity in an in vitro model of UVB-irradiated HaCaT keratinocytes. Furthermore, the new morin semicarbazone derivative significantly enhances the photoprotective, antioxidant, and anti-inflammatory properties of the carotenoid fucoxanthin, being more effective than natural morin. In summary, the compounds are intended for use as adjuvants in sunscreens, whether in solid forms (capsules, tablets) or liquid forms (creams, gels) for oral or topical administration. Additionally, their combined use with other active ingredients, such as fucoxanthin, is proposed to enhance their protective effect.