SYSTEM FOR ADMINISTERING BIOLOGICALLY ACTIVE SUBSTANCES PRODUCED BY FOAMING TECHNIQUES USING COMPRESSED GASES OR SUPERCRITICAL FLUIDS

Patent number:
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The invention relates to a system for administering biologically active substances produced by foaming techniques using compressed gases or supercritical fluids. The invention relates to a porous system containing biologically active substances comprising a polymer matrix of poly(D,L-lactic-co-glycolic acid) or a polymer mixture containing poly(D,L-lactic-co-glycolic acid) of an intrinsic viscosity of less than 0.5 dL/g with other biodegradable synthetic or semisynthetic polyesters, a release-regulating component (starch and derivatives) and at least one biologically active substance, characterised in that it is a biodegradable matrix with a solid or semisolid consistency and a homogeneous appearance. The invention also relates to a method for producing said systems using foaming with compressed fluids, and to the use for the production of implants and scaffolds comprising said system. Optionally, a porogenic agent can be used for the formation of macropores by thermal decomposition.

Countries:
Spain
Regions:
Galicia
Centers:
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Other entities:
Sectors:
Chemicals
Subsectors:
Chemical engineering, Materials, Medical technology
TRL Level:
TRL 4 – technology validated in lab
BRL Level:
PDF Link:
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Video Link:
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Sustainable Development Goal:
Applications

ECOBONE - Advanced Synthetic Bone Grafts  Homogeneous and controlled-formation of pores  Tunable properties to control degradation and release  Solvent-free manufacturing, adequate for thermally sensitive compounds  Easy-scale-up

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