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COMPOSITION AND USE AS A PHOTOPROTECTOR AND PHOTOSTABILIZER
P202530732
Ultraviolet (UV) radiation and high-energy visible light (HEVL) can cause damage to the skin and DNA, including burns, photoaging, hyperpigmentation, immunosuppression, and cancer, also affecting the structure of proteins and cell membranes. The biological response depends on the wavelength and the absorption capacity of molecules with chromophore groups such as keratin, melanin, or nucleic acids, which is studied using action spectra and biologically effective radiation. Although current sunscreens protect well against UVB, protection against UVA and HEVL is less standardized, and factors such as the photostability of the filters and photosensitivity induced by synthetic compounds are significant concerns. Therefore, there is growing interest in natural compounds present in fruits and vegetables, which combine antioxidant and therapeutic effects with the ability to absorb UV-Vis radiation, functioning as natural sun filters and offering protection against oxidative stress and associated diseases. The present invention describes new photoprotective compounds based on phenolic compounds such as chalconaringenin and naringenin.
Its main advantage lies in its ability to increase photoprotective potential in the ultraviolet B spectral region and, especially, in ultraviolet A, as well as its high antioxidant potential, which improves the photostability of the creams to which it is added. Added to this is the fact that these are natural active ingredients and can have a better marketing impact than synthetic excipients. The isolation of chalconaringenin from naringenin is also described, a method that is much simpler and more economical than those found in the industry, where this compound is very expensive to acquire.