FORMULATIONS COMPRISING LIPID SYSTEMS CARRYING BIOACTIVE COMPOUNDS, FOR USE AS IMMUNOTHERAPY POTENTIATORS OR ADJUVANTS FOR PATIENTS WITH CANCER OR IMMUNOLOGICAL DISORDERS

Patent number:

US2019037900

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The present invention relates to a lipid system which not only improves stability during digestion and oral bioavailability of various bioactive compounds in a safe and effective manner, but also in many cases enhances the effects of said compounds. The present invention also relates to formulations or compositions comprising lipid systems carrying bioactive compounds for use as immunotherapy potentiators or adjuvants for patients with cancer or immunological disorders.

Countries:

Spain

Regions:

Community of Madrid

Centers:

FUNDACION IMDEA ALIMENTACION, UNIVERSIDAD AUTONOMA DE MADRID, HOSPITAL UNIVERSITARIO INFANTA SOFIA

Other entities:

Sectors:

Health

Chemicals

Food & Agro

Subsectors:

Food chemistry, Pharmaceuticals

TRL Level:

TRL 9 – actual system proven in operational environment (competitive manufacturing in the case of key enabling technologies; or in space)

BRL Level:

PDF Link:

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Video Link:

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Sustainable Development Goal:

SDG03: Good health and well-being

Applications

The lipid system of the present invention is a self-emulsifying system that forms microemulsions during digestion together with bile salts and phospholipids, forming mixed micelles that stabilise the bioactive components during digestion, preventing their precipitation or interaction with absorption inhibitors and thus increasing their bioaccessibility, bioavailability and, consequently, their bioactivity.

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