USE OF REELIN AS A BIOMARKER FOR INTESTINAL DISEASES
WO20178469
Reelin can be used as a sole biomarker in the diagnosis and identification of various intestinal pathologies and as a biomarker of the transition from an intestinal inflammatory disease to tumorogenesis. The inventors have demonstrated that, in response to tissue damage, such as inflammation, the intestine can respond by increasing the expression of reelin to reinforce the intestinal barrier and facilitate tissue repair. If the inflammation progresses, the conditions that reduce or suppress the expression of reelin are established, wherein said absence favours the formation of an unfavourable microenvironment that would aggravate the inflammation and/or would induce tumorogenesis.
In vitro method to diagnose different phases of an intestinal disease in a subject.



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