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PERSONALIZED IMPLANTS WITH ANTIMICROBIAL ACTIVITY TO PREVENT AND TREAT BONE INFECTIONS
P202230220
Current treatments for surgical site infections caused by fungi or bacteria with antibiotics and antifungals are usually based on prolonged intravenous administration or the use of polymethylmethacrylate cements after removing the prosthesis and cleaning the surrounding tissues, which makes another surgical procedure necessary. . However, a delivery system that avoids high body exposure to the antimicrobial and the patient having to undergo further surgery would be more desirable. The present invention describes 3D printed implants with biocompatible and biodegradable polymers that comprise drugs with an immediate-sustained release with a reduced hemolytic profile, which are easily adherent to prostheses, have a good in vitro efficacy profile against different strains of fungi. and bacteria and can be sterilized by the action of UV light due to its thin thickness.
ADVANTAGES The developed 3D printed implants allow the prophylaxis and treatment of periprosthetic joint infections by placing the implant on the bone and allowing a tunde drug release of one or more broad spectrum antimicrobials. This system does not alter the biomechanical properties of the joint and, ideally, can be placed externally on top of the prosthesis with millimeter thickness having a fast adhesion so that it does not hinder the surgical procedure. APPLICATIONS The direct application of this patent is to be able to develop a 3D implant that can be administered at the time of an arthroplasty of hip, knee or any other prosthesis in order to prevent or treat infections associated with the surgical intervention. It is therefore a novel pharmaceutical formulation.