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CARBOSILANE DENDRIMERS AND THE USE THEREOF AS ANTIVIRAL AGENTS
US2013059818
Highly branched macromolecules synthesized from a polyfunctional core, preferably silicon, or polyphenolic, with a carbosilane structure at its periphery functionalized with groups, preferably anionic, giving to the macromolecule a net negative charge. Furthermore, the invention relates to the procedures for their synthesis and their uses as antiviral agents, antibacterial and antifungal agents.
The anti-inflammatory properties of these dendrimers are additional advantages with respect to other dendrimers with antiviral, antibacterial or antipyretic activity. In addition to the prophylactic application, they have therapeutic effect especially in sexually transmitted diseases, by preventing the infection of cells not yet infected. Their preparation as pharmaceutical formula can be very varied, being possible any solid composition (tablets, pills, capsules, granules, etc.) or liquid (gels, solutions, suspensions or emulsions). For oral, nasal, topical or parenteral administration, preferably the administration will be topical. These dendrimers by themselves have biological activity as antiviral agents. They have in vitro activity against a variety of viruses