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SALTS OF PYRIDAZINO[2,3-A]PYRROLO[2,1-C]QUINOXALINE FOR THE TREATMENT OF LEISHMANIA INFECTIONS AND DISEASES THAT INVOLVE THE PROTEIN TYROSINE PHOSPHATASE 1B
WO15004304
The invention relates to novel compounds of formula (I), to methods for preparing same, to the use thereof as growth inhibitors of the Leishmania parasite and/or as inhibitors of the protein tyrosine phosphatase 1B (PTP1B), to the use of the intermediate products that lead to said compounds for preparing a growth inhibitor of the Leishmania parasite and/or an inhibitor of PTP1B included in said formula, and to the use of the pharmaceutical compositions that contain said compounds for the treatment of diseases caused by infection with the Leishmania parasite and/or diseases in which the PTP1B is involved in the pathogenesis thereof.
High specificity for the Leishmania parasite. Possible new therapy for diabetes and obesity. As leishmanicidal, these compounds are highly selective. They can be used with other pharmaceuticals or additional active principles to provide a combination therapy.