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RODENT MODEL FOR FIBROMYALGIA AND CHRONIC PAIN (MACHINE-TRANSLATION BY GOOGLE TRANSLATE, NOT LEGALLY BINDING)
ES2525072
The object of the present invention refers to a rodent model for fibromyalgia and chronic pain, induced by pharmacological and nutritional treatments, as well as the evaluation of the response by cerebral imaging tests. It has been shown that by partially inhibiting the levels of coenzyme q in rodents, the most common symptoms of fibromyalgia are reproduced, such as pain, depression, anxiety, memory and sleep disorders as well as all the biological alterations described in the literature. Disease such as inflammation, oxidative stress, serotonin deficiency. On the other hand, it also demonstrates the overexpression of a pain marker gene, which provides us with a molecular tool for the evaluation and control of pain.
Este modelo reproduce tanto sintomatología como bioquímica propias de la fibromialgia: dolor, depresión, ansiedad, trastorno de la memoria y del sueño y las alteraciones biológicas descritas como inflamación, estrés oxidativo, déficit de serotonina. Es un modelo fácil de generar, debido a que se realiza por administración repetida de un único fármaco. Se trata de una herramienta molecular para la evaluación del dolor generalizado, además de la fibromialgia, nunca antes patentada.