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METHOD FOR DIAGNOSING CELIAC DISEASE BASED ON THE LEVEL OF EXPRESSION OF THE UBE2L3 GENE
Patent number:
US2022186299
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The present invention relates to methods for the diagnosis of celiac disease based on the quantification of the expression level of the UBE2L3 gene, as well as of the relative expression of isoform 2 of the UBE2L3 gene with respect to the total expression of the said gene. Likewise, the invention relates to kits with the means needed to perform the diagnosis according to the methods of the invention.
Countries:
Spain
Regions:
Basque Country
Centers:
EUSKAL HERRIKO UNBERTSITATEA
Other entities:
Sectors:
Health
Subsectors:
Biotechnology
TRL Level:
TRL 3 – experimental proof of concept
BRL Level:
PDF Link:
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Watch it hereSustainable Development Goal:
SDG03: Good health and well-being
Applications
• Method for the diagnosis of CeD in PBMCs isolated from peripheral blood. • Method for the diagnosis of CeD in individuals that have initiated a GFD before medical consultation. • No need for gluten-provocation. • No need for endoscopy. • Easy PCR-based method for the detection of the relative expression of gene isoforms.
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