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CSC-BASED MALIGNANT MELANOMA MODEL BY 3D-BIOPRINTING
A new tri-layered malignant melanoma 3D model has been developed by 3D bioprinting, and based on cancer stem cells. This model reproduces the heterogeneity and complexity of the tumor microenvironment, and would comprise an alternative to animal testing and clinical trials for cancer diagnosis, prognosis and treatment studies.
- Higher model fidelity It more accurately replicates celular components, the tri-layer structure and microenvironment tan current 2D, and 3D in vitro models. - Overcomes difficulties associated with current 3D in vitro models Such as limited vascularization, lack of wellorganized spatial distribution of the biological components, and oversimplified structure. - High standardization, scalability and repeatability of assays Thanks to the optimized generation via bioprinting, which favors asset commercialization. - Ethic alternative to animal testing The use of a skin model reduces the need of animal testing, and it can even reduce the need of clinical trials. - Time and resource savings Linked to the reduced use of experimental animals and the conduction of clinical trials.