Novel Probiotic Strain for the prevention and treatment of metabolic syndrome-related disturbances.

- Clinically relevant anti‑obesity potential Demonstrates a significant reduction in fat accumulation in vivo, even under high‑glucose (obesogenic) conditions. - Mechanism‑based metabolic action Activates peroxisomal β‑oxidation pathways and modulates insulin/IGF‑1 signaling (FOXO/DAF‑16), providing a clear and differentiated mode of action compared to non‑mechanistic probiotics. - Enhanced oxidative stress protection Reduces intracellular reactive oxygen species (ROS) and improves antioxidant response, supporting overall metabolic health and healthy aging. - Lifespan extension effects Proven ability to extend lifespan in vivo, positioning the strain beyond weight management toward health‑span and longevity applications. - Dual metabolic and immunomodulatory functionality Combines metabolic benefits with immune modulation, including regulation of pro‑ and anti‑inflammatory cytokines. - Pathogen exclusion capacity Reduces adhesion of E. coli O157:H7 to intestinal epithelial cells, contributing to gut barrier protection. - High probiotic robustness and safety profile Fully sensitive to clinically relevant antibiotics (EFSA‑compliant), strong resistance to gastric and intestinal conditions, and no cytotoxic effects in cellular models. - Production of beneficial metabolites Produces short‑chain fatty acids, particularly acetate, associated with body weight regulation and glucose homeostasis. - Strain‑specific, not genus‑generic, efficacy Effects are scientifically demonstrated for this specific strain, avoiding the common limitation of assuming benefits from species‑level claims. - High readiness for industrial valorization Suitable for integration into functional foods, nutraceuticals, dietary supplements and synbiotic formulations targeting metabolic health.