Procedure for determining the degree of transferrin glycosylation and electrochemical apparatus for carrying out this method.

Advantages Rapid and simple determination of transferrin glycosylation without the need for complex laboratory infrastructure. Portable, low-cost and disposable electrochemical system suitable for point-of-care testing. Low sample volume requirement and short analysis time. High correlation with reference analytical methods (CE-UV). Reduced dependence on expensive instrumentation and highly specialised personnel. Potential for decentralised testing outside central laboratories. Applications In vitro diagnostic (IVD) testing for congenital disorders of glycosylation (CDG). Screening and follow-up of chronic alcohol consumption. Detection of cerebrospinal fluid leakage through transferrin glycoform analysis. Potential use in neonatal screening programmes. Point-of-care diagnostics in hospitals, outpatient clinics and primary care settings.