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ANTIMALARIAL AGENT, METHODS AND USES THEREOF
EP3313807
The present disclosure relates to compound of the formula I wherein R1 is a halogen; R2, R4 are independently selected from a group consisting of C1–C6 alkyl, H, COCH3, COH, CO-alkyl, CO-aryl; R3 is a C3–C30 alkyl; or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, for use in medicine, in particular as antimalarial agent. The present solution relates to halogenated alkyl-aromatic secondary metabolites, in particular hierridin C from the cyanobacterium Cyanobium sp. LEGE 06113 - which was received on 29 May 2015 and accepted for deposit for patent purposes on 15th June 2015 at the Scottish Association for Marine Science Culture Collection of Algae and Protozoa (CCAP) - International Depositary Authority under the Budapest Treaty - under the CCAP number 1436/1- and its application as an antimalarial agent.
The solution now disclosed relates to antimalarial agents and to methods to obtain them. The advantage of the present disclosure is that there is no strain of P. falciparum known to be resistant to halogenated alkyl-aromatic secondary metabolite, in particular hierridin C and its derivatives. This advantage is relevant as death by malaria is almost exclusively caused by P. falciparum.