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Biotin & Thiamine: A novel therapeutic strategy for Huntington’s Disease
Patent number:
WO/2021/058847 (EP, US)
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El metabolismo de la tiamina está alterado en la enfermedad de Huntington. Nuestros estudios in vivo muestran que el tratamiento con tiamina y biotina revierte los síntomas de la enfermedad. Actualmente estamos evaluando la seguridad y tolerabilidad del tratamiento combinado tiamina-biotina en un ensayo clínico multicéntrico con pacientes.
Countries:
Spain
Regions:
Community of Madrid
Centers:
CSIC, CIBERNED CENTRO DE INVESTIG BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS
Other entities:
Sectors:
Health
Subsectors:
TRL Level:
TRL 5 – technology validated in relevant environment (industrially relevant environment in the case of key enabling technologies)
BRL Level:
PDF Link:
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Watch it hereSustainable Development Goal:
Applications
- Improve HD neuropathology, radiology and motor symptoms in mouse model - Proven safety and good tolerability in human Good treatment adherance in human - ODD eligible - Allows combination therapy with other treatments
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